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hla specific antibody detection kit  (Thermo Fisher)


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    Structured Review

    Thermo Fisher hla specific antibody detection kit
    Univariate logistic regression analysis for PTR and P/P PTR.
    Hla Specific Antibody Detection Kit, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hla+specific+antibody+detection+kit/pmc11703460-156-6-14
    Average 90 stars, based on 1 article reviews
    hla specific antibody detection kit - by Bioz Stars, 2026-09
    90/100 stars

    Images

    1) Product Images from "Existence and significance of anti-HLA-C autoantibodies to primary and persistent platelet transfusion refractoriness in patients with hematologic disorders: a retrospective study from a single centre"

    Article Title: Existence and significance of anti-HLA-C autoantibodies to primary and persistent platelet transfusion refractoriness in patients with hematologic disorders: a retrospective study from a single centre

    Journal: Annals of Medicine

    doi: 10.1080/07853890.2024.2446689

    Univariate logistic regression analysis for PTR and P/P PTR.
    Figure Legend Snippet: Univariate logistic regression analysis for PTR and P/P PTR.

    Techniques Used:

     Anti-HLA   Antibodies  distribution.
    Figure Legend Snippet: Anti-HLA Antibodies distribution.

    Techniques Used:

    The platelet transfusion response based on locus of HLA-I subgroups. The occurrence rate of overall (A) and primary (B) platelet transfusion efficacy was compared based on locus of HLA-I subgroups, and found that either anti-HLA-A, HLA-B or HLA-C antibody positive contribute to the ineffective to the platelet transfusion (all p < .05).
    Figure Legend Snippet: The platelet transfusion response based on locus of HLA-I subgroups. The occurrence rate of overall (A) and primary (B) platelet transfusion efficacy was compared based on locus of HLA-I subgroups, and found that either anti-HLA-A, HLA-B or HLA-C antibody positive contribute to the ineffective to the platelet transfusion (all p < .05).

    Techniques Used:

    Multivariate logistic regression identify anti-HLA-C autoantibodies as the risk factor for primary and persistent (P/P) platelet transfusion refractoriness. Factors with a univariate logistic regression result of p < .1 were included in the multivariate logistic regression analysis. The multivariate logistic regression analysis revealed that anti-HLA-I antibodies were an independent risk factor for PTR (2 A), but not in P/P PTR (2B); anti-HLA-C antibody was an independent risk factor for overall PTR (2 C), but not for P/P PTR (2D). Considering that anti-HLA-C antibody and anti-HLA-C autoantibody can be confounding factors, only anti-HLA-C autoantibody was selected for logistic regression analysis alongside anti-HLA-a and B antibodies. Result showed that no factors could predict the occurrence of PTR (2E), while anti-HLA-C autoantibody positive was the independent risk factor for P/P PTR (2 F). PTR: platelet transfusion refractoriness.
    Figure Legend Snippet: Multivariate logistic regression identify anti-HLA-C autoantibodies as the risk factor for primary and persistent (P/P) platelet transfusion refractoriness. Factors with a univariate logistic regression result of p < .1 were included in the multivariate logistic regression analysis. The multivariate logistic regression analysis revealed that anti-HLA-I antibodies were an independent risk factor for PTR (2 A), but not in P/P PTR (2B); anti-HLA-C antibody was an independent risk factor for overall PTR (2 C), but not for P/P PTR (2D). Considering that anti-HLA-C antibody and anti-HLA-C autoantibody can be confounding factors, only anti-HLA-C autoantibody was selected for logistic regression analysis alongside anti-HLA-a and B antibodies. Result showed that no factors could predict the occurrence of PTR (2E), while anti-HLA-C autoantibody positive was the independent risk factor for P/P PTR (2 F). PTR: platelet transfusion refractoriness.

    Techniques Used:

    Comparison of baseline characteristics in patients with or without  anti-HLA-C  autoantibodies in  anti-HLA-C  antibody positive population.
    Figure Legend Snippet: Comparison of baseline characteristics in patients with or without anti-HLA-C autoantibodies in anti-HLA-C antibody positive population.

    Techniques Used: Comparison

    Comparison Of the ABO-D matched and cross-matching platelet transfusions efficiency in patients with or without anti-HLA-C autoantibodies in anti-HLA-C antibody positive population. Significant differences were observed in both effective ordinary ( p < .001, 3 A) and cross-matching ( p = .017, 3B) platelet transfusion between patients with or without anti-HLA-C autoantibodies ( n = 6 vs. n = 26).
    Figure Legend Snippet: Comparison Of the ABO-D matched and cross-matching platelet transfusions efficiency in patients with or without anti-HLA-C autoantibodies in anti-HLA-C antibody positive population. Significant differences were observed in both effective ordinary ( p < .001, 3 A) and cross-matching ( p = .017, 3B) platelet transfusion between patients with or without anti-HLA-C autoantibodies ( n = 6 vs. n = 26).

    Techniques Used: Comparison

    Details of patients with positive  anti-HLA-C  autoantibodies.
    Figure Legend Snippet: Details of patients with positive anti-HLA-C autoantibodies.

    Techniques Used:

    Related Articles

    Purification:

    Article Title: Existence and significance of anti-HLA-C autoantibodies to primary and persistent platelet transfusion refractoriness in patients with hematologic disorders: a retrospective study from a single centre
    Article Snippet: .. Meanwhile, HLA antibodies were detected using HLA specific antibody detection kit (LABScreen ® , ONE LAMBDA), which utilize purified HLA antigen-coated microbeads to detect HLA antibodies by flow cytometry, and it defined mean fluorescent intensity (MFI) >500 as positive for an antibody [ ]. ..

    Flow Cytometry:

    Article Title: Existence and significance of anti-HLA-C autoantibodies to primary and persistent platelet transfusion refractoriness in patients with hematologic disorders: a retrospective study from a single centre
    Article Snippet: .. Meanwhile, HLA antibodies were detected using HLA specific antibody detection kit (LABScreen ® , ONE LAMBDA), which utilize purified HLA antigen-coated microbeads to detect HLA antibodies by flow cytometry, and it defined mean fluorescent intensity (MFI) >500 as positive for an antibody [ ]. ..



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    Image Search Results


    Univariate logistic regression analysis for PTR and P/P PTR.

    Journal: Annals of Medicine

    Article Title: Existence and significance of anti-HLA-C autoantibodies to primary and persistent platelet transfusion refractoriness in patients with hematologic disorders: a retrospective study from a single centre

    doi: 10.1080/07853890.2024.2446689

    Figure Lengend Snippet: Univariate logistic regression analysis for PTR and P/P PTR.

    Article Snippet: Meanwhile, HLA antibodies were detected using HLA specific antibody detection kit (LABScreen ® , ONE LAMBDA), which utilize purified HLA antigen-coated microbeads to detect HLA antibodies by flow cytometry, and it defined mean fluorescent intensity (MFI) >500 as positive for an antibody [ ].

    Techniques:

     Anti-HLA   Antibodies  distribution.

    Journal: Annals of Medicine

    Article Title: Existence and significance of anti-HLA-C autoantibodies to primary and persistent platelet transfusion refractoriness in patients with hematologic disorders: a retrospective study from a single centre

    doi: 10.1080/07853890.2024.2446689

    Figure Lengend Snippet: Anti-HLA Antibodies distribution.

    Article Snippet: Meanwhile, HLA antibodies were detected using HLA specific antibody detection kit (LABScreen ® , ONE LAMBDA), which utilize purified HLA antigen-coated microbeads to detect HLA antibodies by flow cytometry, and it defined mean fluorescent intensity (MFI) >500 as positive for an antibody [ ].

    Techniques:

    The platelet transfusion response based on locus of HLA-I subgroups. The occurrence rate of overall (A) and primary (B) platelet transfusion efficacy was compared based on locus of HLA-I subgroups, and found that either anti-HLA-A, HLA-B or HLA-C antibody positive contribute to the ineffective to the platelet transfusion (all p < .05).

    Journal: Annals of Medicine

    Article Title: Existence and significance of anti-HLA-C autoantibodies to primary and persistent platelet transfusion refractoriness in patients with hematologic disorders: a retrospective study from a single centre

    doi: 10.1080/07853890.2024.2446689

    Figure Lengend Snippet: The platelet transfusion response based on locus of HLA-I subgroups. The occurrence rate of overall (A) and primary (B) platelet transfusion efficacy was compared based on locus of HLA-I subgroups, and found that either anti-HLA-A, HLA-B or HLA-C antibody positive contribute to the ineffective to the platelet transfusion (all p < .05).

    Article Snippet: Meanwhile, HLA antibodies were detected using HLA specific antibody detection kit (LABScreen ® , ONE LAMBDA), which utilize purified HLA antigen-coated microbeads to detect HLA antibodies by flow cytometry, and it defined mean fluorescent intensity (MFI) >500 as positive for an antibody [ ].

    Techniques:

    Multivariate logistic regression identify anti-HLA-C autoantibodies as the risk factor for primary and persistent (P/P) platelet transfusion refractoriness. Factors with a univariate logistic regression result of p < .1 were included in the multivariate logistic regression analysis. The multivariate logistic regression analysis revealed that anti-HLA-I antibodies were an independent risk factor for PTR (2 A), but not in P/P PTR (2B); anti-HLA-C antibody was an independent risk factor for overall PTR (2 C), but not for P/P PTR (2D). Considering that anti-HLA-C antibody and anti-HLA-C autoantibody can be confounding factors, only anti-HLA-C autoantibody was selected for logistic regression analysis alongside anti-HLA-a and B antibodies. Result showed that no factors could predict the occurrence of PTR (2E), while anti-HLA-C autoantibody positive was the independent risk factor for P/P PTR (2 F). PTR: platelet transfusion refractoriness.

    Journal: Annals of Medicine

    Article Title: Existence and significance of anti-HLA-C autoantibodies to primary and persistent platelet transfusion refractoriness in patients with hematologic disorders: a retrospective study from a single centre

    doi: 10.1080/07853890.2024.2446689

    Figure Lengend Snippet: Multivariate logistic regression identify anti-HLA-C autoantibodies as the risk factor for primary and persistent (P/P) platelet transfusion refractoriness. Factors with a univariate logistic regression result of p < .1 were included in the multivariate logistic regression analysis. The multivariate logistic regression analysis revealed that anti-HLA-I antibodies were an independent risk factor for PTR (2 A), but not in P/P PTR (2B); anti-HLA-C antibody was an independent risk factor for overall PTR (2 C), but not for P/P PTR (2D). Considering that anti-HLA-C antibody and anti-HLA-C autoantibody can be confounding factors, only anti-HLA-C autoantibody was selected for logistic regression analysis alongside anti-HLA-a and B antibodies. Result showed that no factors could predict the occurrence of PTR (2E), while anti-HLA-C autoantibody positive was the independent risk factor for P/P PTR (2 F). PTR: platelet transfusion refractoriness.

    Article Snippet: Meanwhile, HLA antibodies were detected using HLA specific antibody detection kit (LABScreen ® , ONE LAMBDA), which utilize purified HLA antigen-coated microbeads to detect HLA antibodies by flow cytometry, and it defined mean fluorescent intensity (MFI) >500 as positive for an antibody [ ].

    Techniques:

    Comparison of baseline characteristics in patients with or without  anti-HLA-C  autoantibodies in  anti-HLA-C  antibody positive population.

    Journal: Annals of Medicine

    Article Title: Existence and significance of anti-HLA-C autoantibodies to primary and persistent platelet transfusion refractoriness in patients with hematologic disorders: a retrospective study from a single centre

    doi: 10.1080/07853890.2024.2446689

    Figure Lengend Snippet: Comparison of baseline characteristics in patients with or without anti-HLA-C autoantibodies in anti-HLA-C antibody positive population.

    Article Snippet: Meanwhile, HLA antibodies were detected using HLA specific antibody detection kit (LABScreen ® , ONE LAMBDA), which utilize purified HLA antigen-coated microbeads to detect HLA antibodies by flow cytometry, and it defined mean fluorescent intensity (MFI) >500 as positive for an antibody [ ].

    Techniques: Comparison

    Comparison Of the ABO-D matched and cross-matching platelet transfusions efficiency in patients with or without anti-HLA-C autoantibodies in anti-HLA-C antibody positive population. Significant differences were observed in both effective ordinary ( p < .001, 3 A) and cross-matching ( p = .017, 3B) platelet transfusion between patients with or without anti-HLA-C autoantibodies ( n = 6 vs. n = 26).

    Journal: Annals of Medicine

    Article Title: Existence and significance of anti-HLA-C autoantibodies to primary and persistent platelet transfusion refractoriness in patients with hematologic disorders: a retrospective study from a single centre

    doi: 10.1080/07853890.2024.2446689

    Figure Lengend Snippet: Comparison Of the ABO-D matched and cross-matching platelet transfusions efficiency in patients with or without anti-HLA-C autoantibodies in anti-HLA-C antibody positive population. Significant differences were observed in both effective ordinary ( p < .001, 3 A) and cross-matching ( p = .017, 3B) platelet transfusion between patients with or without anti-HLA-C autoantibodies ( n = 6 vs. n = 26).

    Article Snippet: Meanwhile, HLA antibodies were detected using HLA specific antibody detection kit (LABScreen ® , ONE LAMBDA), which utilize purified HLA antigen-coated microbeads to detect HLA antibodies by flow cytometry, and it defined mean fluorescent intensity (MFI) >500 as positive for an antibody [ ].

    Techniques: Comparison

    Details of patients with positive  anti-HLA-C  autoantibodies.

    Journal: Annals of Medicine

    Article Title: Existence and significance of anti-HLA-C autoantibodies to primary and persistent platelet transfusion refractoriness in patients with hematologic disorders: a retrospective study from a single centre

    doi: 10.1080/07853890.2024.2446689

    Figure Lengend Snippet: Details of patients with positive anti-HLA-C autoantibodies.

    Article Snippet: Meanwhile, HLA antibodies were detected using HLA specific antibody detection kit (LABScreen ® , ONE LAMBDA), which utilize purified HLA antigen-coated microbeads to detect HLA antibodies by flow cytometry, and it defined mean fluorescent intensity (MFI) >500 as positive for an antibody [ ].

    Techniques: